amino)methylene)amino)- ethanesulfonicacid,2-(((methoxycarbonyl)amino)((2-nitro-5-(propylthio)phenyl) hapasil Neviyapine
NETOBIMIN
CAS: 88255-01-0
Molecular Formula: C14H20N4O7S2
amino)methylene)amino)- ethanesulfonicacid,2-(((methoxycarbonyl)amino)((2-nitro-5-(propylthio)phenyl) hapasil Neviyapine - Names and Identifiers
| Name | NETOBIMIN |
| Synonyms | NETOBIMIN amino)methylene)amino)- ethanesulfonicacid,2-(((methoxycarbonyl)amino)((2-nitro-5-(propylthio)phenyl) hapasil Neviyapine |
| CAS | 88255-01-0 |
amino)methylene)amino)- ethanesulfonicacid,2-(((methoxycarbonyl)amino)((2-nitro-5-(propylthio)phenyl) hapasil Neviyapine - Physico-chemical Properties
| Molecular Formula | C14H20N4O7S2 |
| Molar Mass | 420.46 |
| Storage Condition | 2-8℃ |
amino)methylene)amino)- ethanesulfonicacid,2-(((methoxycarbonyl)amino)((2-nitro-5-(propylthio)phenyl) hapasil Neviyapine - Non-nucleoside reverse transcriptase inhibitor nevirapine
From Wanfang Medicine
Author:
Tu Guogang ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(eb589091be8eea7a) author:(Li Shaohua)" target = "_blank"> Li Shaohua
Summary:
AIDS is an infectious disease that seriously threatens human health. It is caused by HIV, especially HIV 1. Nevirapine is a new type of non-nucleoside reverse transcriptase inhibitor, which can be used in combination with nucleoside reverse transcriptase inhibitors or protease inhibitors to treat AIDS, and alone can be used to prevent HIV infection and mother-to-child transmission
keywords:
pharmacology overview nevirapine non-nucleoside reverse transcriptase inhibitors href = "https://xueshu.baidu.com/s?wd=艾滋病&tn=SE_baiduxueshu_c1gjeupa&ie=utf-8" target = "_blank"> AIDS Drug therapy
DOI:
10.3969/j.issn.1009-2501.2003.06.002
cited:
Year:
2003
Last Update：2024-01-02 23:10:35
amino)methylene)amino)- ethanesulfonicacid,2-(((methoxycarbonyl)amino)((2-nitro-5-(propylthio)phenyl) hapasil Neviyapine - Synthesis of nevirapine
From HowNet
Author:
Meng Qingwei ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(488 f501773c6c8d6) author:(Zeng Wei)" target = "_blank"> Zeng Wei ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(267 e036b735cd463) author:(Lai Qiong)" target = "_blank"> Lai Qi/a >,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(99 b91f7d490c587) author:(Li Yueqing)" target = "_blank"> Li Yueqing ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(58824875 d556a9e7) author:(Zhao Weijie)" target = "_blank"> Zhao Weijie
Summary:
Cyanoacetamide and ethyl acetoacetate undergo condensation cyclization, chlorination, cyanohydrolysis, Hoffman degradation, catalytic hydrogen release of chlorine, selective chlorination to produce 2-chloro-3-amino-4-methylpyridine, and then undergo amidation with 2-chloronicotinyl chloride, cyclopropylamine nucleophilic substitution and closed-loop reaction to generate nevirapine, with a total yield of 39%.
keywords:
nevirapine reverse transcriptase inhibitor antiviral drug synthesis
DOI:
10.3969/j.issn.1001-8255.2006.01.003
cited:
Year:
2006
Last Update：2023-08-16 22:23:51
amino)methylene)amino)- ethanesulfonicacid,2-(((methoxycarbonyl)amino)((2-nitro-5-(propylthio)phenyl) hapasil Neviyapine - New Progress in Synthesis of Anti-AIDS Drug Nevirapine
From HowNet
Author:
Xu Qingqing ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(5490 c9a2f5a2c7b1) author:(Yang Yiwen)" target = "_blank"> Yang Yiwen
Summary:
nevirapine (NVP) is one of the most widely used anti-AIDS drugs at present, and the research on its synthetic method has received extensive attention in recent years. The author introduces the latest progress of the synthesis technology of this compound at home and abroad, analyzes 6 synthetic routes, discusses the advantages and disadvantages of each synthesis method, and looks forward to the development of its synthesis technology.
keywords:
nevirapine; anti-AIDS drug; synthesis
DOI:
10.3321/j.issn:1003-3734.2008.13.001
cited:
Year:
2008
Last Update：2023-08-16 22:23:51
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amino)methylene)amino)- ethanesulfonicacid,2-(((methoxycarbonyl)amino)((2-nitro-5-(propylthio)phenyl) hapasil Neviyapine
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